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ea0032p1099 | Thyroid cancer | ECE2013

The prevalence, the tumorigenic role and the functional implications of rare BRAF alterations in a cohort of Italian patients with thyroid carcinomas

Pezzani Raffaele , Barollo Susi , Cristiani Andrea , Redaelli Marco , Zambonin Laura , Rubin Beatrice , Bertazza Loris , Zane Mariangela , Mucignat-Caretta Carla , Bulfone Alessandro , Pennelli Gianmaria , Rosa Pelizzo Maria , Mantero Franco , Moro Stefano , Mian Caterina

Background: Papillary thyroid carcinoma (PTC) is the most common malignant tumor of the thyroid gland, accounting for 7480% of all thyroid cancers. The T1799T>A transversion is an activating mutation of the BRAF oncogene that is common in conventional PTC and specific to it.Aims: To study the prevalence, tumorigenic role and biomolecular implications of rare BRAF variants in a large cohort of patients.Study desig...

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The prevalence, the tumorigenic role and the functional implications of rare BRAF alterations in a cohort of Italian patients with thyroid carcinomas

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